ACVA Protein (AA 21-426) (His tag)
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- Antigène Voir toutes ACVA Protéines
- ACVA (Activin A (ACVA))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 21-426
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette ACVA protéine est marqué à la His tag.
- Application
- Functional Studies (Func)
- Séquence
- AA 21-426
- Attributs du produit
- This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 13 kDa (mature) & 32 kDa (pro). As a result of glycosylation and Interchain disulfide bond, the protein migrates as 15 kDa (mature) and 43-48 kDa (pro) under reducing (R) condition, and 27 kDa (mature), 43-48 kDa (pro) and 60 kDa (pro & mature) under non-reducing (NR) condition (SDS-PAGE).
- Pureté
- >95 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product ACVA Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
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- Antigène
- ACVA (Activin A (ACVA))
- Autre désignation
- Activin A (ACVA Produits)
- Synonymes
- inhibin beta A subunit Protein, Inhba Protein
- Sujet
- Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion. Activins are nonglycosylated homodimers or heterodimers of various β subunits (βA, βB, βC, and βE in mammals), while Inhibins are heterodimers of a unique α subunit and one of the β subunits. Activin A is a widely expressed homodimer of two βA chains. The βA subunit can also heterodimerize with a βB or βC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human βA chain shares 100 % amino acid sequence identity with bovine, feline, mouse, porcine, and rat βA. Activin is produced in the gonads, pituitary gland, placenta, and other organs. The bioactivity of Activin A is regulated by a variety of mechanisms. In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization, Activin is strongly expressed in wounded skin, and overexpression of activin in epidermis of transgenic mice improves wound healing and enhances scar formation, Activin also regulates the morphogenesis of branching organs such as the prostate, lung, and especially kidney. Activin A increased the expression level of type-I collagen suggesting that activin A acts as a potent activator of fibroblasts, Lack of activin during development results in neural developmental defects.
- Poids moléculaire
- 13.0 kDa (mature) and 32.0 kDa (pro)
- Pathways
- Hormone Transport, Peptide Hormone Metabolism
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