LRRC32 Protein (partial) (Fc Tag)

N° du produit ABIN5608431

Détail du produit

Antigène: LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: partial

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette LRRC32 protéine est marqué à la Fc Tag.

Application: Western Blotting (WB), ELISA

Séquence: His 20 - Asn 627

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Endotoxin level is less than 1.0 EU per ug by the LAL method.

Biological Activity Comment:

Measured by its binding ability in a functional ELISA. Immobilized Latent TGFB1, N-His at 5 μg/mL (100 uL/well) can bind Human LRRC32, Fc Tag with a linear range of 0.039-2.5 μg/mL (QC tested).

Information d'application

Indications d'application: This recombinant protein can be used for E, WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, pH 7.5

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C,-80 °C

Stockage commentaire: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.

Détail du antigène

Antigène: LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))

Autre désignation: LRRC32 (LRRC32 Produits)

Synonymes: D11S833E Protein, GARP Protein, AI426318 Protein, D11S833Eh Protein, D7H11S833E Protein, EG434215 Protein, Garp Protein, leucine rich repeat containing 32 Protein, LRRC32 Protein, Lrrc32 Protein

Sujet: Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naive T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naive T cell proliferation.

Poids moléculaire: 92.6 kDa

ID gène: 2615

Pathways: Activated T Cell Proliferation