LRRC32 Protein (AA 20-627) (Fc Tag)

N° du produit ABIN5674638

Détail du produit

Antigène: LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))

Type de proteíne: Recombinant

Attributs du protein: AA 20-627

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette LRRC32 protéine est marqué à la Fc Tag.

Séquence: AA 20-627

Attributs du produit: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 92.6 kDa. The protein migrates as 35 kDa and 100-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Détail du antigène

Antigène: LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))

Autre désignation: LRRC32 (LRRC32 Produits)

Synonymes: D11S833E Protein, GARP Protein, AI426318 Protein, D11S833Eh Protein, D7H11S833E Protein, EG434215 Protein, Garp Protein, leucine rich repeat containing 32 Protein, LRRC32 Protein, Lrrc32 Protein

Sujet: Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naive T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naive T cell proliferation.

Poids moléculaire: 92.4 kDa

NCBI Accession: NP_005503

Pathways: Activated T Cell Proliferation