Complement Factor B Protein (CFB) (AA 23-761) (His tag)

N° du produit ABIN5709279

Détail du produit

Antigène: Complement Factor B (CFB)

Type de proteíne: Recombinant

Attributs du protein: AA 23-761

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Complement Factor B protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: TPVLEARPQV SCSLEGVEIK GGSFQLLQGG QALEYLCPSG FYPYPVQTRT CRSTGSWSDL QTRDQKIVQK AECRAIRCPR PQDFENGEFW PRSPFYNLSD QISFQCYDGY VLRGSANRTC QENGRWDGQT AICDDGAGYC PNPGIPIGTR KVGSQYRLED IVTYHCSRGL VLRGSQKRKC QEGGSWSGTE PSCQDSFMYD SPQEVAEAFL SSLTETIEGA DAEDGHSPGE QQKRKIVLDP SGSMNIYLVL DGSDSIGSSN FTGAKRCLTN LIEKVASYGV RPRYGLLTYA TVPKVLVRVS DERSSDADWV TEKLNQISYE DHKLKSGTNT KRALQAVYSM MSWAGDAPPE GWNRTRHVII IMTDGLHNMG GNPVTVIQDI RALLDIGRDP KNPREDYLDV YVFGVGPLVD SVNINALASK KDNEHHVFKV KDMEDLENVF YQMIDETKSL SLCGMVWEHK KGNDYHKQPW QAKISVTRPL KGHETCMGAV VSEYFVLTAA HCFMVDDQKH SIKVSVGGQR RDLEIEEVLF HPKYNINGKK AEGIPEFYDY DVALVKLKNK LKYGQTLRPI CLPCTEGTTR ALRLPQTATC KQHKEQLLPV KDVKALFVSE QGKSLTRKEV YIKNGDKKAS CERDATKAQG YEKVKDASEV VTPRFLCTGG VDPYADPNTC KGDSGGPLIV HKRSRFIQVG VISWGVVDVC RDQRRQQLVP SYARDFHINL FQVLPWLKDK LKDEDLGFL

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: Complement Factor B (CFB)

Autre désignation: CFAB (CFB Produits)

Synonymes: AHUS4 Protein, BF Protein, BFD Protein, CFAB Protein, FB Protein, FBI12 Protein, GBG Protein, H2-Bf Protein, PBF2 Protein, bf Protein, Bf-1 Protein, Brre-Bf Protein, zgc:114032 Protein, Bf Protein, Sp152 Protein, bfb-A Protein, Bf B Protein, LOC397725 Protein, bf/c2 Protein, CFB Protein, AI195813 Protein, AI255840 Protein, B Protein, C2 Protein, Fb Protein, Da1-24 Protein, complement factor B Protein, complement factor B S homeolog Protein, complement factor B L homeolog Protein, CFB Protein, cfb Protein, bf Protein, cfb.S Protein, cfb.L Protein, bf/c2 Protein, LOC100555981 Protein, Cfb Protein

Sujet: Factor B which is part of the alternate pathway of the complent syst is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complent factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

Poids moléculaire: 86.9 kDa

UniProt: P00751

Pathways: Système du Complément, Proton Transport, Ribonucleoside Biosynthetic Process