EIF4EBP2
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
> 80 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Format
Liquid
Concentration
0.1-2 mg/mL
Buffer
20 mM Tris-HCl based buffer, pH 8.0
Stock
-80 °C,4 °C,-20 °C
Stockage commentaire
Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Antigène
eIF4EBP2 (EIF4EBP2)
(Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2))
4ebp2 Protein, MGC75579 Protein, wu:fa55e11 Protein, wu:fp45e09 Protein, MGC78987 Protein, EIF4EBP2 Protein, eIF-4E Protein, Tb06.28P18.1010 Protein, 4EBP2 Protein, PHASII Protein, 2810011I19Rik Protein, 4E-BP2 Protein, AA792569 Protein, BC010348 Protein, PHAS-II Protein, eukaryotic translation initiation factor 4E binding protein 2 Protein, eukaryotic translation initiation factor 4E binding protein 2 L homeolog Protein, eukaryotic initiation factor 4E Protein, eukaryotic translation initiation factor 4E Protein, putative eukaryotic translation initiation factor 4e Protein, eif4ebp2 Protein, Eif4ebp2 Protein, eif4ebp2.L Protein, EIF4EBP2 Protein, eIF-4E Protein, Tb927.6.1870 Protein, LMJF_30_0450 Protein
Sujet
Repressor of translation initiation involved in synaptic plasticity, learning and mory formation . Regulates EIF4E activity by preventing its assbly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation . EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal st cell renewal via its ability to repress translation initiation . Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways .