GDF5 Protein (AA 376-495) (His tag)
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- Antigène Voir toutes GDF5 Protéines
- GDF5 (Growth Differentiation Factor 5 (GDF5))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 376-495
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Origine
- Souris
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette GDF5 protéine est marqué à la His tag.
- Application
- SDS-PAGE (SDS)
- Séquence
- APLANRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR
- Purification
- SDS-PAGE
- Pureté
- > 90 %
- Top Product
- Discover our top product GDF5 Protéine
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Growth Differentiation Factor 5 (GDF5) (AA 376-495) protein (His tag)
GDF5 Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Growth Differentiation Factor 5 (GDF5) (AA 382-501) protein (His-IF2DI Tag)GDF5 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Growth Differentiation Factor 5 (GDF5) (AA 28-127) protein (GST tag)GDF5 Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AA, AP
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Stock
- -80 °C,4 °C,-20 °C
- Stockage commentaire
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Antigène
- GDF5 (Growth Differentiation Factor 5 (GDF5))
- Autre désignation
- GDF5 (GDF5 Produits)
- Synonymes
- CDMP1 Protein, gdf Protein, gdf-5 Protein, GDF5 Protein, BDA1C Protein, BMP14 Protein, LAP4 Protein, OS5 Protein, SYM1B Protein, SYNS2 Protein, Cdmp-1 Protein, bp Protein, brp Protein, Cdmp1 Protein, growth differentiation factor 5 L homeolog Protein, growth differentiation factor 5 Protein, gdf5.L Protein, GDF5 Protein, Gdf5 Protein
- Sujet
- Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction . Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG . Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 . Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes .
- Poids moléculaire
- 17.7 kDa
- UniProt
- P43027
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