HDAC3 Protein (AA 1-428, full length) (His-SUMO Tag)

N° du produit ABIN5709651

Détail du produit

Antigène: HDAC3 (Histone Deacetylase 3 (HDAC3))

Type de proteíne: Recombinant

Attributs du protein: full length, AA 1-428

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette HDAC3 protéine est marqué à la His-SUMO Tag.

Application: SDS-PAGE (SDS)

Séquence: MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP YQASQHDMCR FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL FEFCSRYTGA SLQGATQLNN KICDIAINWA GGLHHAKKFE ASGFCYVNDI VIGILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI NQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLDQIRQ TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP EENYSRPEAP NEFYDGDHDN DKESDVEI

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: HDAC3 (Histone Deacetylase 3 (HDAC3))

Autre désignation: HDAC3 (HDAC3 Produits)

Synonymes: CG2128 Protein, DHDAC3 Protein, DmHDAC3 Protein, Dmel\\CG2128 Protein, Dromel_CG2128_FBtr0078767_hdac3_mORF Protein, HDAC Protein, HDAC3 Protein, Hdac 3 Protein, dHDAC3 Protein, dmHDA402 Protein, hdac3 Protein, HDm Protein, hd3 Protein, RPD3 Protein, XRpd3 Protein, rpd3-2 Protein, HD3 Protein, RPD3-2 Protein, AW537363 Protein, zgc:55927 Protein, Histone deacetylase 3 Protein, histone deacetylase 3 Protein, histone deacetylase 3 S homeolog Protein, HDAC3 Protein, hdac3 Protein, CNL05260 Protein, Hdac3 Protein, hdac3.S Protein

Sujet: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elents, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation . Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI3K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress .

Poids moléculaire: 64.8 kDa

UniProt: O15379

Pathways: Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development