LRP4 Protein (AA 1747-1905) (His tag)

N° du produit ABIN4975552

Détail du produit

Antigène: LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))

Type de proteíne: Recombinant

Attributs du protein: AA 1747-1905

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette LRP4 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: YRHKKSKFTD PGMGNLTYSN PSYRTSTQEV KIEAIPKPAM YNQLCYKKEG GPDHNYTKEK IKIVEGICLL SGDDAEWDDL KQLRSSRGGL LRDHVCMKTD TVSIQASSGS LDDTETEQLL QEEQSECSSV HTAATPERRG SLPDTGWKHE RKLSSESQV

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))

Autre désignation: LRP4 (LRP4 Produits)

Synonymes: CLSS Protein, LRP-4 Protein, LRP10 Protein, MEGF7 Protein, SOST2 Protein, Megf7 Protein, 6430526J12Rik Protein, D230026E03 Protein, mdig Protein, LRP4 Protein, lrp10 Protein, megf7 Protein, LDL receptor related protein 4 Protein, low density lipoprotein receptor-related protein 4 Protein, LRP4 Protein, Lrp4 Protein, lrp4 Protein

Sujet: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic mbrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.

Poids moléculaire: 22 kDa

UniProt: O75096

Pathways: Skeletal Muscle Fiber Development