RYR1 Protein (AA 1-534, partial) (His tag)

N° du produit ABIN5710288

Détail du produit

Antigène: RYR1 (Ryanodine Receptor 1 (Skeletal) (RYR1))

Type de proteíne: Recombinant

Attributs du protein: AA 1-534, partial

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette RYR1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGDAEGEDEV QFLRTDDEVV LQCSATVLKE QLKLCLAAEG FGNRLCFLEP TSNAQNVPPD LAICCFVLEQ SLSVRALQEM LANTVEAGVE SSQGGGHRTL LYGHAILLRH AHSRMYLSCL TTSRSMTDKL AFDVGLQEDA TGEACWWTMH PASKQRSEGE KVRVGDDIIL VSVSSERYLH LSTASGELQV DASFMQTLWN MNPICSRCEE GFVTGGHVLR LFHGHMDECL TISPADSDDQ RRLVYYEGGA VCTHARSLWR LEPLRISWSG SHLRWGQPLR VRHVTTGQYL ALTEDQGLVV VDASKAHTKA TSFCFRISKE KLDVAPKRDV EGMGPPEIKY GESLCFVQHV ASGLWLTYAA PDPKALRLGV LKKKAMLHQE GHMDDALSLT RCQQEESQAA RMIHSTNGLY NQFIKSLDSF SGKPRGSGPP AGTALPIEGV ILSLQDLIIY FEPPSEDLQH EEKQSKLRSL RNRQSLFQEE GMLSMVLNCI DRLNVYTTAA HFAEFAGEEA AESWKEIVNL LYELLASLIR GNRS

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: RYR1 (Ryanodine Receptor 1 (Skeletal) (RYR1))

Autre désignation: RYR1 (RYR1 Produits)

Synonymes: ryr1 Protein, RYR1 Protein, alphaRYR Protein, CCO Protein, MHS Protein, MHS1 Protein, RYDR Protein, RYR Protein, RYR-1 Protein, SKRR Protein, Ryr1l Protein, CRC Protein, AI528790 Protein, Ryr Protein, skrr Protein, ryanodine receptor 1 Protein, ryanodine receptor 1 (skeletal) Protein, ryanodine receptor 1a (skeletal) Protein, ryanodine receptor 1, skeletal muscle Protein, RYR1 Protein, ryr1a Protein, Ryr1 Protein

Sujet: Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm. Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain. Required for normal bryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during bryogenesis .

Poids moléculaire: 63.4 kDa

UniProt: P21817

Pathways: Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development