Sortilin 1 Protein (SORT1) (AA 610-754) (His-SUMO Tag)

N° du produit ABIN5710402

Détail du produit

Antigène: Sortilin 1 (SORT1)

Type de proteíne: Recombinant

Attributs du protein: AA 610-754

Origine: Rat

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Sortilin 1 protéine est marqué à la His-SUMO Tag.

Application: SDS-PAGE (SDS)

Séquence: CEENDYTTWL AHSTDPGDYK DGCILGYKEQ FLRLRKSSVC QNGRDYVVAK QPSICPCSLE DFLCDFGYFR PENASECVEQ PELKGHELEF CLYGKEEHLT TNGYRKIPGD RCQGGMNPAR EVKDLKKKCT SNFLNPKKQN SKSSS

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: Sortilin 1 (SORT1)

Autre désignation: SORT (SORT1 Produits)

Synonymes: SORT1 Protein, 19.m02079 Protein, gp95 Protein, ldlcq6 Protein, sortilin Protein, Gp95 Protein, LDLCQ6 Protein, NT3 Protein, 2900053A11Rik Protein, AI852375 Protein, Ntr3 Protein, Ntsr3 Protein, Nt3 Protein, Nts3 Protein, sort1 Protein, zgc:85953 Protein, sortilin 1 Protein, sortilin Protein, sortilin 1 S homeolog Protein, sortilin 1a Protein, SORT1 Protein, TP01_0016 Protein, BBOV_I002730 Protein, sort1.S Protein, Sort1 Protein, sort1a Protein

Sujet: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.

Poids moléculaire: 32.5 kDa

UniProt: O54861

Pathways: Neurotrophin Signaling Pathway