IFNK Protein (AA 24-195) (His tag)

N° du produit ABIN5710800

Détail du produit

Antigène: IFNK (Interferon, kappa (IFNK))

Type de proteíne: Recombinant

Attributs du protein: AA 24-195

Origine: Boeuf (Vache)

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette IFNK protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: CYLSEDHMLG ARENLRLLAR MNRLSPHPCL QDRKDFGLPQ EMVEGNQLQK DQAISVLHEM LQQCFNLFYT EHSSAAWNTT LLEQLCTGLQ QQLEDLDACL GPVMGEKDSD MGRMGPILTV KKYFQGIHVY LKEKEYSDCA WEIIRVEMMR ALSSSTTLQK RLRKMGGDLN SL

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: IFNK (Interferon, kappa (IFNK))

Autre désignation: IFNT1 (IFNK Produits)

Synonymes: IFNK Protein, IFNT1 Protein, INFE1 Protein, RP11-27J8.1 Protein, interferon kappa Protein, IFNK Protein, Ifnk Protein

Sujet: Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.

Poids moléculaire: 23.8 kDa

UniProt: P15696