ESR2 Protein (AA 2-530) (His tag)

N° du produit ABIN5713440

Détail du produit

Antigène: ESR2 (Estrogen Receptor 2 (ESR2))

Type de proteíne: Recombinant

Attributs du protein: AA 2-530

Origine: Humain

Source: Levure

Purification/Conjugué: Cette ESR2 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: DIKNSPSSLN SPSSYNCSQS ILPLEHGSIY IPSSYVDSHH EYPAMTFYSP AVMNYSIPSN VTNLEGGPGR QTTSPNVLWP TPGHLSPLVV HRQLSHLYAE PQKSPWCEAR SLEHTLPVNR ETLKRKVSGN RCASPVTGPG SKRDAHFCAV CSDYASGYHY GVWSCEGCKA FFKRSIQGHN DYICPATNQC TIDKNRRKSC QACRLRKCYE VGMVKCGSRR ERCGYRLVRR QRSADEQLHC AGKAKRSGGH APRVRELLLD ALSPEQLVLT LLEAEPPHVL ISRPSAPFTE ASMMMSLTKL ADKELVHMIS WAKKIPGFVE LSLFDQVRLL ESCWMEVLMM GLMWRSIDHP GKLIFAPDLV LDRDEGKCVE GILEIFDMLL ATTSRFRELK LQHKEYLCVK AMILLNSSMY PLVTATQDAD SSRKLAHLLN AVTDALVWVI AKSGISSQQQ SMRLANLLML LSHVRHASNK GMEHLLNMKC KNVVPVYDLL LEMLNAHVLR GCKSSITGSE CSPAEDSKSK EGSQNPQSQ

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: ESR2 (Estrogen Receptor 2 (ESR2))

Autre désignation: ESR2 (ESR2 Produits)

Synonymes: ER-BETA Protein, ESR-BETA Protein, ESRB Protein, ESTRB Protein, Erb Protein, NR3A2 Protein, ER[b]1 Protein, zfER-beta1 Protein, zfER[b]1 Protein, erb2 Protein, CERB Protein, ERB Protein, erb Protein, esrb Protein, estrb Protein, nr3a2 Protein, ERbeta Protein, er-beta Protein, esr-beta Protein, ESR2 Protein, ERBETA Protein, er Protein, ER-beta Protein, ER[b] Protein, Estrb Protein, ER[b]2 Protein, ER[b]a Protein, zfER[b]2 Protein, zfER-beta2 Protein, Erb2 Protein, esr2 Protein, erbeta Protein, Esr2 Protein, ERBeta2 Protein, estrogen receptor 2 Protein, estrogen receptor 2b Protein, estrogen receptor beta 2 Protein, estrogen receptor 2 (beta) Protein, estrogen receptor 2a Protein, estrogen receptor beta Protein, ESR2 Protein, esr2b Protein, erb2 Protein, esr2 Protein, Esr2 Protein, esr2a Protein, erbeta Protein

Sujet: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elents (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated tperature is more gradual.

Poids moléculaire: 60 kDa

UniProt: Q92731

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling