GBA Protein (AA 53-89) (His tag)

N° du produit ABIN5713466

Détail du produit

Antigène: GBA (Glucosidase, Beta, Acid (GBA))

Type de proteíne: Recombinant

Attributs du protein: AA 53-89

Origine: Humain

Source: Levure

Purification/Conjugué: Cette GBA protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: HSQGTFTSDY SKYLDSRRAQ DFVQWLMNTK RNRNNIA

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: GBA (Glucosidase, Beta, Acid (GBA))

Autre désignation: GLUC (GBA Produits)

Synonymes: GBA1 Protein, GCB Protein, GLUC Protein, BETA-GLUCOSIDASE Protein, T12J13.8 Protein, T12J13_8 Protein, beta glucosidase 25 Protein, PSPTO3318 Protein, PSPTO4290 Protein, GC Protein, GCase Protein, betaGC Protein, glucosylceramidase beta Protein, beta glucosidase 25 Protein, beta-glucosidase Protein, Beta-glucosidase Protein, glucosidase, beta, acid Protein, glucosylceramidase Protein, bglX-2 Protein, GBA Protein, BGLU25 Protein, PSPTO_3318 Protein, bglX Protein, bglA4 Protein, Gba Protein, LOC100399524 Protein, bglA.2 Protein, bglX-2 Protein

Sujet: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycia. Plays an important role in initiating and maintaining hyperglycic conditions in diabetes.GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis.GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.Oxyntomodulin significantly reduces food intake. Inhibits gastric ptying in humans. Suppression of gastric ptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.

Poids moléculaire: 6.4 kDa

UniProt: P01275

Pathways: Cellular Glucan Metabolic Process