MME Protein (AA 52-750) (His tag)

N° du produit ABIN5713648

Détail du produit

Antigène: MME (Membrane Metallo-Endopeptidase (MME))

Type de proteíne: Recombinant

Attributs du protein: AA 52-750

Origine: Humain

Source: Levure

Purification/Conjugué: Cette MME protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: YDDGICKSSD CIKSAARLIQ NMDATTEPCT DFFKYACGGW LKRNVIPETS SRYGNFDILR DELEVVLKDV LQEPKTEDIV AVQKAKALYR SCINESAIDS RGGEPLLKLL PDIYGWPVAT ENWEQKYGAS WTAEKAIAQL NSKYGKKVLI NLFVGTDDKN SVNHVIHIDQ PRLGLPSRDY YECTGIYKEA CTAYVDFMIS VARLIRQEER LPIDENQLAL EMNKVMELEK EIANATAKPE DRNDPMLLYN KMTLAQIQNN FSLEINGKPF SWLNFTNEIM STVNISITNE EDVVVYAPEY LTKLKPILTK YSARDLQNLM SWRFIMDLVS SLSRTYKESR NAFRKALYGT TSETATWRRC ANYVNGNMEN AVGRLYVEAA FAGESKHVVE DLIAQIREVF IQTLDDLTWM DAETKKRAEE KALAIKERIG YPDDIVSNDN KLNNEYLELN YKEDEYFENI IQNLKFSQSK QLKKLREKVD KDEWISGAAV VNAFYSSGRN QIVFPAGILQ PPFFSAQQSN SLNYGGIGMV IGHEITHGFD DNGRNFNKDG DLVDWWTQQS ASNFKEQSQC MVYQYGNFSW DLAGGQHLNG INTLGENIAD NGGLGQAYRA YQNYIKKNGE EKLLPGLDLN HKQLFFLNFA QVWCGTYRPE YAVNSIKTDV HSPGNFRIIG TLQNSAEFSE AFHCRKNSYM NPEKKCRVW

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: MME (Membrane Metallo-Endopeptidase (MME))

Autre désignation: NEP (MME Produits)

Synonymes: CALLA Protein, CD10 Protein, NEP Protein, SFE Protein, 6030454K05Rik Protein, C85356 Protein, Nep Protein, neprilysin Protein, membrane metalloendopeptidase Protein, membrane metallo endopeptidase Protein, membrane metallo-endopeptidase Protein, MME Protein, Mme Protein

Classe de substances: Chemical

Sujet: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids . Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond . Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 . Involved in the degradation of atrial natriuretic factor (ANF) . Displays UV-inducible elastase activity toward skin preelastic and elastic fibers .

Poids moléculaire: 81.83 kDa

UniProt: P08473

Pathways: Signalisation RTK, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration