SOCS3 Protein (AA 1-225, full length) (His tag)

N° du produit ABIN5713856

Détail du produit

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Type de proteíne: Recombinant

Attributs du protein: full length, AA 1-225

Origine: Rat

Source: Levure

Purification/Conjugué: Cette SOCS3 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL SAEPAGTFLI RDSSDQRHFF TLSVETQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV LKLVHHYMPP PGAPSFSLPP TEPSFEVQEQ PPAQALPGGT PKRAYYIYSG GEKIPLVLSR PLSSNVATLQ HLCRKTVNGH LDSYEKVTQL PGPIREFLDQ YDAPL

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Autre désignation: SOCS3 (SOCS3 Produits)

Synonymes: socs3 Protein, fj09e12 Protein, zgc:56537 Protein, wu:fj09e12 Protein, MGC64393 Protein, MGC75749 Protein, xsocs3 Protein, MGC81248 Protein, atod4 Protein, cis3 Protein, cish3 Protein, socs-3 Protein, ssi-3 Protein, ssi3 Protein, SOCS3 Protein, ATOD4 Protein, CIS3 Protein, Cish3 Protein, SOCS-3 Protein, SSI-3 Protein, SSI3 Protein, Cis3 Protein, EF-10 Protein, Ef10 Protein, Ssi3 Protein, Socs-3 Protein, Ssi-3 Protein, suppressor of cytokine signaling 3a Protein, suppressor of cytokine signaling 3 S homeolog Protein, suppressor of cytokine signaling 3 Protein, suppressor of cytokine signaling 3 L homeolog Protein, socs3a Protein, socs3.S Protein, socs3 Protein, socs3.L Protein, SOCS3 Protein, Socs3 Protein

Sujet: SOCS family proteins form part of a classical negative feedback syst that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ses to recognize IL6ST .

Poids moléculaire: 26.81 kDa

UniProt: O88583

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus, Hepatitis C