FUS Protein (AA 27-529) (His tag)

N° du produit ABIN5714158

Détail du produit

Antigène: FUS (Fused in Sarcoma (FUS))

Type de proteíne: Recombinant

Attributs du protein: AA 27-529

Origine: Human respiratory syncytial virus A

Source: Levure

Purification/Conjugué: Cette FUS protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: NITEEFYQST CSAVSKGYLS ALRTGWYTSV ITIELSNIKE NKCNGTDAKV KLIKQELDKY KNAVTELQLL MQSTPPTNNR ARRELPRFMN YTLNNAKKTN VTLSKKRKRR FLGFLLGVGS AIASGVAVSK VLHLEGEVNK IKSALLSTNK AVVSLSNGVS VLTSKVLDLK NYIDKQLLPI VNKQSCSISN IETVIEFQQK NNRLLEITRE FSVNAGVTTP VSTYMLTNSE LLSLINDMPI TNDQKKLMSN NVQIVRQQSY SIMSIIKEEV LAYVVQLPLY GVIDTPCWKL HTSPLCTTNT KEGSNICLTR TDRGWYCDNA GSVSFFPQAE TCKVQSNRVF CDTMNSLTLP SEINLCNVDI FNPKYDCKIM TSKTDVSSSV ITSLGAIVSC YGKTKCTASN KNRGIIKTFS NGCDYVSNKG MDTVSVGNTL YYVNKQEGKS LYVKGEPIIN FYDPLVFPSD EFDASISQVN EKINQSLAFI RKSDELLHNV NAGKSTTNIM ITT

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: FUS (Fused in Sarcoma (FUS))

Autre désignation: FUS (FUS Produits)

Synonymes: ALS6 Protein, ETM4 Protein, FUS1 Protein, HNRNPP2 Protein, POMP75 Protein, TLS Protein, D430004D17Rik Protein, D930039C12Rik Protein, Fus1 Protein, Tls Protein, FUS/TLS Protein, FUS RNA binding protein Protein, fused in sarcoma Protein, FUS Protein, Fus Protein

Classe de substances: Viral Protein

Sujet: During virus entry, induces fusion of viral and cellular mbranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2 . Interacts directly with heparan sulfate and may participates in virus attachment . Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity . Later in infection, proteins F expressed at the plasma mbrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis .

Poids moléculaire: 57.91 kDa

UniProt: P03420