FUS Protein (AA 136-608) (His-SUMO Tag)

N° du produit ABIN5710740

Détail du produit

Antigène: FUS (Fused in Sarcoma (FUS))

Type de proteíne: Recombinant

Attributs du protein: AA 136-608

Origine: Canine Distemper Virus (CDV)

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette FUS protéine est marqué à la His-SUMO Tag.

Application: SDS-PAGE (SDS)

Séquence: QIHWDNLSTI GIIGTDNVHY KIMTRPSHQY LVIKLIPNAS LIENCTKAEL GEYEKLLNSV LEPINQALTL MTKNVKPLQS LGSGRRQRRF AGVVLAGVAL GVATAAQITA GIALHQSNLN AQAIQSLRTS LEQSNKAIEE IREATQETVI AVQGVQDYVN NELVPAMQHM SCELVGQRLG LRLLRYYTEL LSIFGPSLRD PISAEISIQA LIYALGGEIH KILEKLGYSG SDMIAILESR GIKTKITHVD LPGKFIILSI SYPTLSEVKG VIVHRLEAVS YNIGSQEWYT TVPRYIATNG YLISNFDESS CVFVSESAIC SQNSLYPMSP LLQQCIRGDT SSCARTLVSG TMGNKFILSK GNIVANCASI LCKCYSTSTI INQSPDKLLT FIASDTCPLV EIDGATIQVG GRQYPDMVYE GKVALGPAIS LDRLDVGTNL GNALKKLDDA KVLIDSSNQI LETVRRSSFN FGS

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: FUS (Fused in Sarcoma (FUS))

Autre désignation: FUS (FUS Produits)

Synonymes: ALS6 Protein, ETM4 Protein, FUS1 Protein, HNRNPP2 Protein, POMP75 Protein, TLS Protein, D430004D17Rik Protein, D930039C12Rik Protein, Fus1 Protein, Tls Protein, FUS/TLS Protein, FUS RNA binding protein Protein, fused in sarcoma Protein, FUS Protein, Fus Protein

Classe de substances: Viral Protein

Sujet: Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell mbrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell mbranes. Directs fusion of viral and cellular mbranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell mbrane. The trimer of F1-F2 (F protein) probably interacts with H at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular mbrane, inducing the fusion between cell and virion mbranes. Later in infection, F proteins expressed at the plasma mbrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis .

Poids moléculaire: 67.5 kDa

UniProt: P12569