METRNL Protein (AA 46-311) (His tag)

N° du produit ABIN5714378

Détail du produit

Antigène: METRNL (Meteorin, Glial Cell Differentiation Regulator-Like (METRNL))

Type de proteíne: Recombinant

Attributs du protein: AA 46-311

Origine: Humain

Source: Levure

Purification/Conjugué: Cette METRNL protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: QYSSDRCSWK GSGLTHEAHR KEVEQVYLRC AAGAVEWMYP TGALIVNLRP NTFSPARHLT VCIRSFTDSS GANIYLEKTG ELRLLVPDGD GRPGRVQCFG LEQGGLFVEA TPQQDIGRRT TGFQYELVRR HRASDLHELS APCRPCSDTE VLLAVCTSDF AVRGSIQQVT HEPERQDSAI HLRVSRLYRQ KSRVFEPVPE GDGHWQGRVR TLLECGVRPG HGDFLFTGHM HFGEARLGCA PRFKDFQRMY RDAQERGLNP CEVGTD

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: METRNL (Meteorin, Glial Cell Differentiation Regulator-Like (METRNL))

Autre désignation: METRL (METRNL Produits)

Synonymes: 9430048M07Rik Protein, BC019776 Protein, fc90a08 Protein, fj23b04 Protein, wu:fc90a08 Protein, wu:fj23b04 Protein, zgc:56225 Protein, meteorin like, glial cell differentiation regulator Protein, meteorin, glial cell differentiation regulator-like Protein, meteorin-like, glial cell differentiation regulator Protein, meteorin, glial cell differentiation regulator-like L homeolog Protein, METRNL Protein, Metrnl Protein, metrnl.L Protein, metrnl Protein

Sujet: Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold tperatures .

Poids moléculaire: 31.96 kDa

UniProt: Q641Q3