SNURF Protein (AA 1-71) (His tag)
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- Antigène Voir toutes SNURF Protéines
- SNURF (SNRPN Upstream Reading Frame (SNURF))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 1-71
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette SNURF protéine est marqué à la His tag.
- Application
- SDS-PAGE (SDS)
- Séquence
- MGSSHHHHHH SSGLVPRGSH MGSMERARDR LHLRRTTEQH VPEVEVQVKR RRTASLSNQE CQLYPRRSQQ QQVPVVDFQA ELRQAFLAET PRGG
- Pureté
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product SNURF Protéine
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.15M NaCl, 40 % glycerol, 1 mM DTT.
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Antigène
- SNURF (SNRPN Upstream Reading Frame (SNURF))
- Autre désignation
- SNuRF (SNURF Produits)
- Synonymes
- 2410045I01Rik Protein, Snrpn Protein, SNRPN upstream reading frame Protein, small nuclear ribonucleoprotein polypeptide N Protein, SNURF Protein, SNRPN Protein, Snurf Protein
- Sujet
- SNuRF is a highly basic protein localized to the nucleus. The evolutionarily constrained open reading frame is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N. The upstream coding region utilizes the first three exons of the transcript, a region that has been identified as an imprinting center. Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region but the full-length nature of these transcripts has not been determined. An alternate exon has been identified that substitutes for exon 4 and leads to a truncated, monocistronic transcript. Alternative splicing or deletion caused by a translocation event in the 5' uTR or coding region of this gene leads to Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. The function of this protein is not yet known. Recombinant human SNuRF protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Poids moléculaire
- 10.8 kDa (94aa) confirmed by MALDI-TOF
- NCBI Accession
- NP_073715
- UniProt
- Q9Y675
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