IYD Protein (AA 24-214) (His tag)

N° du produit ABIN5853588

Détail du produit

Antigène: IYD (Iodotyrosine Deiodinase (IYD))

Type de proteíne: Recombinant

Attributs du protein: AA 24-214

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette IYD protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGSSHHHHHH SSGLVPRGSH MGSDRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNE

Pureté: > 90 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Denatured

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.4M uREA, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: IYD (Iodotyrosine Deiodinase (IYD))

Autre désignation: IYD (IYD Produits)

Synonymes: MGC85450 Protein, C6orf71 Protein, DEHAL1 Protein, TDH4 Protein, dJ422F24.1 Protein, 0610009A07Rik Protein, AI265638 Protein, Dehal1 Protein, RGD1309288 Protein, IYD-1 Protein, iodotyrosine deiodinase Protein, iodotyrosine deiodinase L homeolog Protein, IYD Protein, iyd.L Protein, iyd Protein, Iyd Protein

Sujet: IYD is an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. Recombinant human IYD protein, fused to His-tag at N-terminus, was expressed in E.coli.

Poids moléculaire: 25.1kDa (214aa)

NCBI Accession: NP_001158167

UniProt: Q6PHW0

Pathways: Thyroid Hormone Synthesis