PAICS Protein (AA 1-425) (His tag)

N° du produit ABIN5853635

Détail du produit

Antigène: PAICS (phosphoribosylaminoimidazole Carboxylase, phosphoribosylaminoimidazole Succinocarboxamide Synthetase (PAICS))

Type de proteíne: Recombinant

Attributs du protein: AA 1-425

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette PAICS protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGSSHHHHHH SSGLVPRGSH MGSMATAEVL NIGKKLYEGK TKEVYELLDS PGKVLLQSKD QITAGNAARK NHLEGKAAIS NKITSCIFQL LQEAGIKTAF TRKCGETAFI APQCEMIPIE WVCRRIATGS FLKRNPGVKE GYKFYPPKVE LFFKDDANND PQWSEEQLIA AKFCFAGLLI GQTEVDIMSH ATQAIFEILE KSWLPQNCTL VDMKIEFGVD VTTKEIVLAD VIDNDSWRLW PSGDRSQQKD KQSYRDLKEV TPEGLQMVKK NFEWVAERVE LLLKSESQCR VVVLMGSTSD LGHCEKIKKA CGNFGIPCEL RVTSAHKGPD ETLRIKAEYE GDGIPTVFVA VAGRSNGLGP VMSGNTAYPV ISCPPLTPDW GVQDVWSSLR LPSGLGCSTV LSPEGSAQFA AQIFGLSNHL VWSKLRASIL NTWISLKQAD KKIRECNL

Pureté: > 90 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. 20  mM Tris-HCl buffer (  pH 8.0) containing 20 % glycerol 0.1M NaCl,1  mM DTT

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: PAICS (phosphoribosylaminoimidazole Carboxylase, phosphoribosylaminoimidazole Succinocarboxamide Synthetase (PAICS))

Autre désignation: PAICS (PAICS Produits)

Synonymes: cb293 Protein, sb:cb293 Protein, wu:fa28a05 Protein, GB14262 Protein, DDBDRAFT_0218550 Protein, DDBDRAFT_0230088 Protein, DDB_0218550 Protein, DDB_0230088 Protein, AIRC Protein, AS Protein, ADE2 Protein, ADE2H1 Protein, PAIS Protein, Ade2h1 Protein, Airc Protein, ade2 Protein, airc Protein, paics Protein, pais Protein, 2610511I09Rik Protein, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase Protein, phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase Protein, multifunctional protein ADE2 Protein, phosphoribosylaminoimidazole carboxylase Protein, phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, gene 2 L homeolog Protein, phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase Protein, PAICS Protein, paics Protein, LOC551966 Protein, Tsp_02239a Protein, Tsp_02239 Protein, CNE02500 Protein, purC/E Protein, Paics Protein, paics.2.L Protein

Sujet: PAICS, also known as phosphoribosylaminoimidazole carboxylase, is an enzyme involved in nucleotide biosynthesis and in particular in purine biosynthesis. It catalyzes the conversion of 5'-phosphoribosyl-5-aminoimidazole(AIR) into 5'-phosphoribosyl-4-carboxy-5-aminoimidazole (CAIR) as described in the reaction. Recombinant human PAICS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Poids moléculaire: 49.5 kDa(448aa) confirmed by MALDI-TOF

NCBI Accession: NP_001072992

UniProt: P22234

Pathways: Chromatin Binding