GLUD1 Protein (AA 54-558) (His tag)

N° du produit ABIN5853669

Détail du produit

Antigène: GLUD1 (Glutamate Dehydrogenase 1 (GLUD1))

Type de proteíne: Recombinant

Attributs du protein: AA 54-558

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette GLUD1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGSSHHHHHH SSGLVPRGSH MGSSEAVADR EDDPNFFKMV EGFFDRGASI VEDKLVEDLR TRESEEQKRN RVRGILRIIK PCNHVLSLSF PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG GAKAGVKINP KNYTDNELEK ITRRFTMELA KKGFIGPGID VPAPDMSTGE REMSWIADTY ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFG DKTFVVQGFG NVGLHSMRYL HRFGAKCIAV GESDGSIWNP DGIDPKELED FKLQHGSILG FPKAKPYEGS ILEADCDILI PAASEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER NIMVIPDLYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLMSV QESLERKFGK HGGTIPIVPT AEFQDRISGA SEKDIVHSGL AYTMERSARQ IMRTAMKYNL GLDLRTAAYV NAIEKVFKVY NEAGVTFT

Pureté: > 80 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Denatured

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.4M urea, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: GLUD1 (Glutamate Dehydrogenase 1 (GLUD1))

Autre désignation: GLuD1 (GLUD1 Produits)

Synonymes: GDH Protein, gdh1 Protein, GDH 1 Protein, glud1 Protein, GLUD1 Protein, cb719 Protein, wu:fb16e02 Protein, wu:fb58f12 Protein, wu:fe37f03 Protein, wu:fj43f02 Protein, zgc:192851 Protein, zgc:55630 Protein, GDH1 Protein, GLUD Protein, AI118167 Protein, Gdh-X Protein, Glud Protein, Gludl Protein, Ac2-281 Protein, Gdh1 Protein, Gludeha Protein, MRG-2 Protein, GLUTAMATE DECARBOXYLASE 1 Protein, GLUTAMATE DEHYDROGENASE 1 Protein, MRG7.13 Protein, MRG7_13 Protein, glutamate dehydrogenase 1 Protein, C2H1orf130 Protein, legdh1 Protein, cb622 Protein, wu:fc33g09 Protein, wu:fc66a10 Protein, zgc:77186 Protein, glutamate dehydrogenase 1 Protein, glutamate dehydrogenase 1 S homeolog Protein, glutamate dehydrogenase 1, mitochondrial Protein, glutamate dehydrogenase 1b Protein, glutamate dehydrogenase Protein, non-compact myelin associated protein Protein, glutamate dehydrogenase 1a Protein, GLUD1 Protein, GDH1 Protein, glud1 Protein, glud1.S Protein, LOC693461 Protein, glud1b Protein, Glud1 Protein, HACJB3_RS00320 Protein, LOC100587725 Protein, NCMAP Protein, gdh1 Protein, glud1a Protein

Sujet: Glutamate dehydrogenase 1, mitochondrial precursor, also known as GLuD1, belongs to the Glu/Leu/Phe/Val dehydrogenases family. GLuD1 has a central role in nitrogen metabolism in plants and animals. GLuD1 is found in all organisms and catalyzes the oxidative deamination of 1-glutamate to 2-oxoglutarate. Mutations in the gene encoding GLuD1 causes hyperinsulinism-hyperammonemia syndrome (HHS), which is an inherited condition characterized by high insulin and ammonia levels in the blood. GLuD1 may also be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. Recombinant human GLuD1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Poids moléculaire: 58.4 kDa (528aa)

NCBI Accession: NP_005262

UniProt: P00367

Pathways: Positive Regulation of Peptide Hormone Secretion, L'effet Warburg