CD131 Protein (AA 17-443) (His tag)

N° du produit ABIN5854442

Détail du produit

Antigène: CD131 (CSF2RB) (Colony Stimulating Factor 2 Receptor, Beta (CSF2RB))

Type de proteíne: Recombinant

Attributs du protein: AA 17-443

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette CD131 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: WERSLAGAEE TIPLQTLRCY NDYTSHITCR WADTQDAQRL VNVTLIRRVN EDLLEPVSCD LSDDMPWSAC PHPRCVPRRC VIPCQSFVVT DVDYFSFQPD RPLGTRLTVT LTQHVQPPEP RDLQISTDQD HFLLTWSVAL GSPQSHWLSP GDLEFEVVYK RLQDSWEDAA ILLSNTSQAT LGPEHLMPSS TYVARVRTRL APGSRLSGRP SKWSPEVCWD SQPGDEAQPQ NLECFFDGAA VLSCSWEVRK EVASSVSFGL FYKPSPDAGE EECSPVLREG LGSLHTRHHC QIPVPDPATH GQYIVSVQPR RAEKHIKSSV NIQMAPPSLN VTKDGDSYSL RWETMKMRYE HIDHTFEIQY RKDTATWKDS KTETLQNAHS MALPALEPST RYWARVRVRT SRTGYNGIWS EWSEARSWDT ESVLPMWLEH HHHHH

Pureté: > 95 % by SDS - PAGE

niveau d'endotoxine: < 1.0 EU per 1 microgram of protein (determined by LAL method)

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: CD131 (CSF2RB) (Colony Stimulating Factor 2 Receptor, Beta (CSF2RB))

Autre désignation: Cytokine receptor common subunit beta (CSF2RB Produits)

Synonymes: Csf2rb1 Protein, CSF2RB Protein, cd131 Protein, cdw131 Protein, il3rb Protein, il5rb Protein, il-3rbc Protein, CD131 Protein, CDw131 Protein, IL3RB Protein, IL5RB Protein, SMDP5 Protein, AI848964 Protein, AIC2B Protein, Bc Protein, Csfgmrb Protein, Il3r Protein, Il3rb Protein, Il3rb1 Protein, Il5rb Protein, colony stimulating factor 2 receptor beta common subunit Protein, colony stimulating factor 2 receptor beta common subunit S homeolog Protein, cytokine receptor common subunit beta-like Protein, colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) Protein, CSF2RB Protein, Csf2rb Protein, csf2rb.S Protein, CRCBL Protein, csf2rb Protein

Sujet: CSF2RB, also known as cytokine receptor common subunit beta, is a high affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. This unusual form of receptor assembly likely applies also to IL-3 and IL-5 receptors, providing a structural basis for understanding their mechanism of activation and for the development of therapeutics. Recombinant human CSF2RB, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Poids moléculaire: 49.7kDa (435aa) 40-57kDa (SDS-PAGE under reducing conditions)

NCBI Accession: NP_000386

UniProt: P32927

Pathways: Signalistation JAK/STAT