GDN Protein, GDNPF Protein, PI-7 Protein, PI7 Protein, PN-1 Protein, PN1 Protein, PNI Protein, SERPINE2 Protein, MGC143011 Protein, Gdnpn1 Protein, Pn-1 Protein, Spin4 Protein, B230326M24Rik Protein, PAI-1 Protein, Spi4 Protein, zgc:55929 Protein, serpin family E member 2 Protein, serine (or cysteine) peptidase inhibitor, clade E, member 2 Protein, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 Protein, SERPINE2 Protein, serpine2 Protein, Serpine2 Protein
Sujet
Serpine2, as known as glia-derived nexin, is a member of the Serpin superfamily of the serine protease inhibitors. This protein is a potent inhibitor of thrombin, plasmin and plasminogen activators. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuron-like cells. Also, it is over expression in mice leads to progressive neuronal and motor dysfunction in these animals. Recombinant mouse Serpine2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques
Poids moléculaire
42.9kDa (386aa) 40-57kDa (SDS-PAGE under reducing conditions.)