SERPINE2 Protein (His tag)

N° du produit ABIN7320831

Détail du produit

Antigène: SERPINE2 (serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 2 (SERPINE2))

Type de proteíne: Recombinant

Origine: Souris

Source: Human Cells

Purification/Conjugué: Cette SERPINE2 protéine est marqué à la His tag.

Fonction: Recombinant Mouse SerpinE2/SERPINE2 Protein (His Tag)

Séquence: Ser20-Pro397

Attributs du produit: Recombinant Mouse Serpin E2 is produced by our Mammalian expression system and the target gene encoding Ser20-Pro397 is expressed with a 10His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: SERPINE2 (serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 2 (SERPINE2))

Autre désignation: SerpinE2/SERPINE2 (SERPINE2 Produits)

Synonymes: GDN Protein, GDNPF Protein, PI-7 Protein, PI7 Protein, PN-1 Protein, PN1 Protein, PNI Protein, SERPINE2 Protein, MGC143011 Protein, Gdnpn1 Protein, Pn-1 Protein, Spin4 Protein, B230326M24Rik Protein, PAI-1 Protein, Spi4 Protein, zgc:55929 Protein, serpin family E member 2 Protein, serine (or cysteine) peptidase inhibitor, clade E, member 2 Protein, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 Protein, SERPINE2 Protein, serpine2 Protein, Serpine2 Protein

Sujet:

Background: Serpin E2 is a member of the Serpin superfamily of the serine protease inhibitors. Serpin E2 is apotent inhibitor of thrombin, plasmin and plasminogen activators. It is differentially expressed during neuronal differentiation and is able to transform humanembryonic kidney cells into neuronlikecells. Its over-expressionin mice leads to progressive neuronal and motor dysfunction in these animals. It is also over-expressedin the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples whereas it is weakly expressed in all normal pancreas and chronicpancreatitis tissue samples. It plays an important role in controlling male fertility because its knockout male mice show a marked impairment in fertility from theonset of sexual maturity and its abnormal expression is found in the semen of men with seminal dysfunction.

Synonym: Glia-derived nexin, GDN, Peptidase inhibitor 7, PI-7, Protease nexin 1, PN-1, Protease nexin I, Serine protease-inhibitor 4, Serpin E2, Pi7, Pn1, Spi4

Poids moléculaire: 43.2 kDa

UniProt: Q07235