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N-Cadherin Protein (AA 160-724) (His tag)

CDH2 Origine: Humain Hôte: Baculovirus infected Insect Cells Recombinant > 90 % by SDS - PAGE SDS
N° du produit ABIN5854951
  • Antigène Voir toutes N-Cadherin (CDH2) Protéines
    N-Cadherin (CDH2) (Cadherin 2 (CDH2))
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 160-724
    Origine
    • 13
    • 5
    • 4
    • 1
    Humain
    Source
    • 11
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Baculovirus infected Insect Cells
    Purification/Conjugué
    Cette N-Cadherin protéine est marqué à la His tag.
    Application
    SDS-PAGE (SDS)
    Séquence
    ADPDWVIPPI NLPENSRGPF PQELVRIRSD RDKNLSLRYS VTGPGADQPP TGIFIINPIS GQLSVTKPLD REQIARFHLR AHAVDINGNQ VENPIDIVIN VIDMNDNRPE FLHQVWNGTV PEGSKPGTYV MTVTAIDADD PNALNGMLRY RIVSQAPSTP SPNMFTINNE TGDIITVAAG LDREKVQQYT LIIQATDMEG NPTYGLSNTA TAVITVTDVN DNPPEFTAMT FYGEVPENRV DIIVANLTVT DKDQPHTPAW NAVYRISGGD PTGRFAIQTD PNSNDGLVTV VKPIDFETNR MFVLTVAAEN QVPLAKGIQH PPQSTATVSV TVIDVNENPY FAPNPKIIRQ EEGLHAGTML TTFTAQDPDR YMQQNIRYTK LSDPANWLKI DPVNGQITTI AVLDRESPNV KNNIYNATFL ASDNGIPPMS GTGTLQIYLL DINDNAPQVL PQEAETCETP DPNSINITAL DYDIDPNAGP FAFDLPLSPV TIKRNWTITR LNGDFAQLNL KIKFLEAGIY EVPIIITDSG NPPKSNISIL RVKVCQCDSN GDCTDVDRIV GAGLGTGAHH HHHH
    Pureté
    > 90 % by SDS - PAGE
    niveau d'endotoxine
    < 1.0 EU per 1ug of protein (determined by LAL method)
    Top Product
    Discover our top product CDH2 Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 20 % glycerol.
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
  • Antigène
    N-Cadherin (CDH2) (Cadherin 2 (CDH2))
    Autre désignation
    CDH2 (CDH2 Produits)
    Synonymes
    CD325 Protein, CDHN Protein, CDw325 Protein, NCAD Protein, N-cadherin Protein, cadherin-2 Protein, cdhn Protein, ncad Protein, cdw325 Protein, CDH2 Protein, Cadherin-2 Protein, Ncad Protein, glo Protein, lyr Protein, pac Protein, wu:fb47h04 Protein, cadherin 2 Protein, cadherin 2 S homeolog Protein, cadherin 2, type 1, N-cadherin (neuronal) Protein, CDH2 Protein, cdh2.S Protein, cdh2 Protein, Cdh2 Protein
    Sujet
    CDH2, also known as cadherin-2 isoform 1, is a transmembrane, homophilic glycoprotein belonging to the calcium-dependent cell adhesion molecule family. It plays a role in neurons and later was found to also play a role in cardiac muscle and in cancer metastasis. Its loss promotes tumorigenesis by releasing membrane-bound B-catenin, hence stimulating Wnt signaling. It seems to be involved in tumor development, but this finding is limited in adrenocortical tumors (ACTs). Recombinant human CDH2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
    Poids moléculaire
    62.9kDa (574aa) 70-100kDa (SDS-PAGE under reducing conditions)
    NCBI Accession
    NP_001783
    UniProt
    P19022
    Pathways
    Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane
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