IL-10RA Protein (AA 22-235) (Fc Tag)

N° du produit ABIN6253272

Détail du produit

Antigène: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Type de proteíne: Recombinant

Attributs du protein: AA 22-235

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette IL-10RA protéine est marqué à la Fc Tag.

Fonction: IL-10Ralpha (human):Fc (human) (rec.)

Specificité: The extracellular domain of human IL-10Ralpha (aa 22-235) is fused to the N-terminus of the Fc region of human IgG1.

Attributs du produit: Protein. The extracellular domain of human IL-10Ralpha (aa 22-235) is fused to the N-terminus of the Fc region of human IgG1. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). CD210, also known as IL10RA, is a subunit for the interleukin-10 receptor. IL10RA has also been designated CDW210A (cluster of differentiation W210A). It is structurally related to interferon receptors. CD210 has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. It has been reported that CD210 promotes survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of CD210 leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

Pureté: >98 % (SDS-PAGE)

niveau d'endotoxine: <5EU/mg protein (LAL test, Lonza).

Biological Activity Comment: Measured by its ability to inhibit IL-10-dependent proliferation of MC/9- 2 mouse mast cells.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Conseil sur la manipulation: Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Détail du antigène

Antigène: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Autre désignation: IL-10Ralpha (IL10RA Produits)

Synonymes: IL10R1 Protein, IL10RA Protein, CD210 Protein, CD210a Protein, CDW210A Protein, HIL-10R Protein, IL-10R1 Protein, IL10R Protein, AW553859 Protein, CDw210 Protein, CDw210a Protein, Il10r Protein, mIL-10R Protein, interleukin 10 receptor subunit alpha Protein, interleukin 10 receptor, alpha Protein, IL10RA Protein, Il10ra Protein

Sujet:

Alternate Names/Synonyms: Interleukin-10 Receptor alpha, IL-10RA, CD210, IL-10R1, CDw210a,

Product Description: CD210, also known as IL10RA, is a subunit for the interleukin-10 receptor. IL10RA has also been designated CDW210A (cluster of differentiation W210A). It is structurally related to interferon receptors. CD210 has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. It has been reported that CD210 promotes survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of CD210 leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

Poids moléculaire: ~70kDa (SDS-PAGE)

Pathways: Growth Factor Binding