IL-6 Receptor Protein (AA 20-357) (Fc Tag)
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- Antigène Voir toutes IL-6 Receptor (IL6R) Protéines
- IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 20-357
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Origine
- Souris
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Source
- CHO Cells
- Purification/Conjugué
- Cette IL-6 Receptor protéine est marqué à la Fc Tag.
- Fonction
- IL-6R (mouse):Fc (mouse) (rec.)
- Specificité
- The extracellular domain of mouse IL-6R (aa 20-357) is fused to the N-terminus of the Fc region of mouse IgG2a.
- Attributs du produit
- Protein. The extracellular domain of mouse IL-6R (aa 20-357) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Interleukin 6 receptor (IL-6R, CD126) is a type I cytokine receptor, which is a protein complex consisting of an IL-6 receptor subunit (IL-6R) and interleukin 6 signal transducer glycoprotein 130 (gp130). It is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL-6 and IL-6R are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
- Pureté
- >98 % (SDS-PAGE)
- niveau d'endotoxine
- <0.06EU/μg protein (LAL test, Lonza).
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA.
- Top Product
- Discover our top product IL6R Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Conseil sur la manipulation
- Avoid freeze/thaw cycles.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Antigène
- IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
- Autre désignation
- IL-6R (IL6R Produits)
- Synonymes
- IL6R Protein, il-6ra Protein, CD126 Protein, IL-6R-1 Protein, IL-6RA Protein, IL6Q Protein, IL6RA Protein, IL6RQ Protein, gp80 Protein, IL6R1 Protein, Il6ra Protein, IL-6Ralpha Protein, IL-6R Protein, Il6r Protein, interleukin 6 receptor Protein, interleukin 6 receptor, alpha Protein, IL6R Protein, il6r Protein, Il6r Protein, Il6ra Protein
- Sujet
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Alternate Names/Synonyms: Interleukin-6 Receptor Subunit alpha, IL6RA, CD126
Product Description: Interleukin 6 receptor (IL-6R, CD126) is a type I cytokine receptor, which is a protein complex consisting of an IL-6 receptor subunit (IL-6R) and interleukin 6 signal transducer glycoprotein 130 (gp130). It is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL-6 and IL-6R are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
- Pathways
- Signalistation JAK/STAT, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
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