CD24 Protein (AA 27-53) (Fc Tag)
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- Antigène Voir toutes CD24 Protéines
- CD24 (CD24 Molecule (CD24))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 27-53
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Origine
- Souris
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette CD24 protéine est marqué à la Fc Tag.
- Fonction
- CD24 (mouse):Fc (human) (rec.)
- Specificité
- The extracellular domain of mouse CD24 (aa 27-53) is fused at the C-terminus to the Fc portion of human IgG1.
- Attributs du produit
- Protein. The extracellular domain of mouse CD24 (aa 27-53) is fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.06EU/μg purified protein (LAL test, Lonza). Lyophilized. Contains PBS. Purity: >90 % (SDS-PAGE). CD24 is a highly glycosylated protein expressed as glycosyl-phosphatidyl-inositol (GPI) anchored molecule. It is widely expressed, mainly on T cells, B cells and is upregulated in numerous types of cancers. It has costimulatory activity for antigen specific T cell responses. Polymorphisms of human CD24 are associated with several autoimmune diseases. Recently, a new role as negative regulator of the immune response has been reported. CD24-deficient mice are more sensitive to inflammatory responses. CD24 together with the membrane protein SIGLEC interacts with danger-associated molecular patterns (DAMPs), such as HMGB1, HSP90 or HSP70. CD24/SIGLEC complex may differentially regulate the host response to DAMPs and PAMPs (pathogen-associated molecular patterns).
- Pureté
- >90 % (SDS-PAGE)
- niveau d'endotoxine
- <0.06EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product CD24 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Conseil sur la manipulation
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. PBS containing at least 0.1 % BSA should be used for further dilutions.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Antigène
- CD24 (CD24 Molecule (CD24))
- Autre désignation
- CD24 (CD24 Produits)
- Synonymes
- CD24A Protein, Cd24a Protein, CD24 molecule Protein, CD24 Protein, Cd24 Protein
- Sujet
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Alternate Names/Synonyms: M1/69-J11D Heat Stable Antigen, Nectadrin, Lymphocyte Antigen 52, X62 Heat Stable Antigen (HSA), Ly-52
Product Description: CD24 is a highly glycosylated protein expressed as glycosyl-phosphatidyl-inositol (GPI) anchored molecule. It is widely expressed, mainly on T cells, B cells and is upregulated in numerous types of cancers. It has costimulatory activity for antigen specific T cell responses. Polymorphisms of human CD24 are associated with several autoimmune diseases. Recently, a new role as negative regulator of the immune response has been reported. CD24-deficient mice are more sensitive to inflammatory responses. CD24 together with the membrane protein SIGLEC interacts with danger-associated molecular patterns (DAMPs), such as HMGB1, HSP90 or HSP70. CD24/SIGLEC complex may differentially regulate the host response to DAMPs and PAMPs (pathogen-associated molecular patterns).
- UniProt
- P25063
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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