TCL1A Protein (AA 1-114)

N° du produit ABIN666894

Détail du produit

Antigène: TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))

Type de proteíne: Recombinant

Attributs du protein: AA 1-114

Origine: Humain

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Attributs du produit: TCL1A, 1-114 aa, Human, Recombinant, E.coli

Pureté: > 90 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 50mM Tris-HCl buffer (pH7.5) containing 10% glycerol

Stock: 4 °C

Détail du antigène

Antigène: TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))

Autre désignation: TCL1A (TCL1A Produits)

Synonymes: TCL1A Protein, Tcl1a Protein, TCL1 Protein, Tcl1 Protein, T-cell leukemia/lymphoma 1A Protein, T cell lymphoma breakpoint 1 Protein, TCL1A Protein, Tcl1 Protein, Tcl1a Protein

Sujet: TCL1A, also known as T-cell leukemia/lymphoma 1A, is a protein with a suggested role in intracellular regulation of T cell signaling. TCL1A binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity TCL1A may enhance the serine/threonine phosphorylation of major Akt signaling substrates, such as Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors, and GSK3b. These substrates regulate cellular differentiation, growth, survival, and metabolism. Recombinant TCL1A protein was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: TCL1, TCL-1, protein p14TCL1, Oncogene TCL1, T-cell leukemia/lymphoma 1A anti TCL1A, P14 TCL1, P14 TCL1 protein, T cell leukemia 1, T cell lymphoma 1, T cell lymphoma 1A, TCL 1 protein, TCL1 oncogene, TCL1 PEN, TCL1A, TCL1A. NCBI no.: NP_001092195

Poids moléculaire: 13.4 kDa (114aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)

Pathways: Stem Cell Maintenance