RGS17 Protein (AA 1-210) (His tag)

N° du produit ABIN667548

Détail du produit

Antigène: RGS17 (Regulator of G-Protein Signaling 17 (RGS17))

Type de proteíne: Recombinant

Attributs du protein: AA 1-210

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette RGS17 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Attributs du produit: RGS17, 1-210aa, Human, His tag, E.coli

Pureté: > 90 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/ml (determined by Bradford assay)

Buffer: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 0.1M NaCl,1mM DTT

Stock: 4 °C

Détail du antigène

Antigène: RGS17 (Regulator of G-Protein Signaling 17 (RGS17))

Autre désignation: RGS17 (RGS17 Produits)

Synonymes: RGS17 Protein, zgc:92802 Protein, MGC179306 Protein, RGS-17 Protein, RGSZ2 Protein, hRGS17 Protein, 6430507P11Rik Protein, Rgsz2 Protein, regulator of G protein signaling 17 Protein, regulator of G-protein signaling 17 Protein, RGS17 Protein, Rgs17 Protein, rgs17 Protein

Sujet: RGS17, also known as regulator of G-protein signaling 17, attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. It plays an important role in termination of signalling by mu opioid receptors and development of tolerance to opioid analgesic drugs. Recombinant human RGS17 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Regulator of G-protein signaling 17, hRGS17, RGS-17, RGSZ2. NCBI no.: NP_036551

Poids moléculaire: 26.5 kDa(230aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling