DTNBP1 Protein (AA 1-270) (His tag)

N° du produit ABIN667731

Détail du produit

Antigène: DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))

Type de proteíne: Recombinant

Attributs du protein: AA 1-270

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette DTNBP1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Attributs du produit: Dysbindin, 1-270aa, Human, His-tagged, Recombinant, E.coli

Pureté: > 95 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: In 20 mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl, 0.5mM DTT, 20% glycerol

Stock: 4 °C

Détail du antigène

Antigène: DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))

Autre désignation: Dysbindin (DTNBP1 Produits)

Synonymes: 5430437B18Rik Protein, AW048963 Protein, Bloc1s8 Protein, dysbindin Protein, sdy Protein, BLOC1S8 Protein, DBND Protein, HPS7 Protein, My031 Protein, SDY Protein, dtnbp1 Protein, zgc:56462 Protein, MGC83903 Protein, dbnd Protein, hps7 Protein, my031 Protein, MGC85477 Protein, DTNBP1 Protein, CG6856 Protein, Ddysb Protein, Dmel\\CG6856 Protein, si:ch211-285p6.1 Protein, dystrobrevin binding protein 1 Protein, Dysbindin Protein, dystrobrevin binding protein 1a Protein, dystrobrevin binding protein 1 L homeolog Protein, dystrobrevin binding protein 1 S homeolog Protein, dystrobrevin binding protein 1b Protein, Dtnbp1 Protein, DTNBP1 Protein, dtbp1 Protein, dtnbp1a Protein, dtnbp1.L Protein, dtnbp1.S Protein, dtnbp1 Protein, Dysb Protein, dtnbp1b Protein

Sujet: Dysbindin is a ubiquitously expressed protein that binds to alpha- and beta-dystrobrevins, components of the dystrophin-associated protein complex (DPC) in both muscle and nonmuscle cells. Dysbindin has been strongly implicated in schizophrenia (SZ) susceptibility by a series of independent genetic association and gene expression studies. Among its known functions, dysbindin is part of a protein complex, termed the biogenesis of lysosome-related organelles complex 1 (BLOC-1), the molecular components of which might be involved in the regulation of vesicular trafficking and dendrite branching. Dysbindin effects for brain volume and cortical thickness appear driven by different neurobiological processes. Recombinant human Dysbindin protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: DTNBP1, DBND, HPS7, SDY, Dystrobrevin-binding protein 1 isoform C Dystrobrevin binding protein 1, Hermansky Pudlak syndrome 7 protein. NCBI no.: NP_898862

Poids moléculaire: 34.6 kDa (307aa), confirmed by MALDI-TOF.

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling