DCK Protein (AA 1-260) (His tag)

N° du produit ABIN667827

Détail du produit

Antigène: DCK (Deoxycytidine Kinase (DCK))

Type de proteíne: Recombinant

Attributs du protein: AA 1-260

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette DCK protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Attributs du produit: DCK, 1-260aa, Human, His tag, E.coli

Pureté: > 90 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 1 mM DTT, 0.1 mM PMSF, 2mM EDTA, 10% Glycerol

Stock: 4 °C

Détail du antigène

Antigène: DCK (Deoxycytidine Kinase (DCK))

Autre désignation: DCK (DCK Produits)

Synonymes: dck Protein, DCK Protein, wu:fc15f06 Protein, zgc:101771 Protein, dck1 Protein, deoxycytidine kinase Protein, deoxycytidine kinase, gene 2 L homeolog Protein, deoxycytidine kinase, gene 2 Protein, Deoxycytidine kinase Protein, deoxycytidine kinase, gene 1 L homeolog Protein, DCK Protein, dck Protein, dck.2.L Protein, dck.2 Protein, Dck Protein, FPV059 Protein, FPV151 Protein, dck.1.L Protein

Sujet: DCK is a key enzyme in the salvage of deoxyribonucleosides and in the activation of clinically relevant nucleoside analogues. This protein is responsible for the 5`-phosphorylation of purine and pyrimidine deoxynucleosides to the corresponding monophosphates using ATP or UTP as phosphate donors. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. Recombinant human DCK protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: MGC117410, MGC138632, Deoxycytidine kinase. NCBI no.: NP_000779

Poids moléculaire: 34.6 kDa(296aa), confirmed by MALDI-TOF