SCO2 Protein (AA 42-266) (His tag)

N° du produit ABIN667861

Détail du produit

Antigène: SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))

Type de proteíne: Recombinant

Attributs du protein: AA 42-266

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette SCO2 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Attributs du produit: SCO2, 42-266aa, Human, His tag, E.coli

Pureté: > 90 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5mg/ml (determined by Bradford assay)

Buffer: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 30% glycerol, 2mM DTT, 200mM NaCl

Stock: 4 °C

Détail du antigène

Antigène: SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))

Autre désignation: SCO2 (SCO2 Produits)

Synonymes: CEMCOX1 Protein, MYP6 Protein, SCO1L Protein, SCO cytochrome oxidase deficient homolog 2 (yeast) Protein, SCO2 cytochrome c oxidase assembly protein Protein, SCO2, cytochrome c oxidase assembly protein Protein, SCO2 Protein, Sco2 Protein

Sujet: SCO2 protein belongs to the SCO1/2 family of proteins. Both SCO1 and SCO2 proteins are located on the inner membrane of the mitochondria and plays a crucial role in copper insertion or transport to the active site of cytochrome c oxidase (COX). Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC). This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies. Recombinant human SCO2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Protein SCO2 homolog mitochondrial, SCO1L. NCBI no.: NP_005129

Poids moléculaire: 27.4kDa (246aa), confirmed by MALDI-TOF

Pathways: Transition Metal Ion Homeostasis, L'effet Warburg