Ecop Protein, RGD1306494 Protein, ecop Protein, gasp Protein, ECOP Protein, GASP Protein, AW146242 Protein, vesicular, overexpressed in cancer, prosurvival protein 1 Protein, vesicular, overexpressed in cancer, prosurvival protein 1 S homeolog Protein, si:dkey-24c2.9 Protein, EGFR-coamplified and overexpressed protein Protein, Vopp1 Protein, vopp1.S Protein, vopp1 Protein, si:dkey-24c2.9 Protein, VOPP1 Protein, ecop Protein
Sujet
Vesicular, overexpressed in cancer, prosurvival protein 1(VOPP1), also known as Glioblastoma-amplified secreted protein (GASP), has been previously shown to be over-expressed in human glioblastoma multiforme and squamous cell carcinoma. VOPP1 is a key regulator of NF-kappaB signaling, and that high-level, amplification-mediated VOPP1 expression, such as that occurring in tumors with amplified EGFR, could contribute to resistance to apoptosis. Recombinant human VOPP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Vesicular, overexpressed in cancer, prosurvival protein 1, ECOP, GASP. NCBI no.: NP_110423