NAE1 Protein (AA 1-534) (His tag)

N° du produit ABIN668001

Détail du produit

Antigène: NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))

Type de proteíne: Recombinant

Attributs du protein: AA 1-534

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette NAE1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Attributs du produit: NAE1, 1-534aa, Human, His tag, E.coli

Pureté: > 90 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% glycerol, 200mM NaCl

Stock: 4 °C

Détail du antigène

Antigène: NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))

Autre désignation: NAE1 (NAE1 Produits)

Synonymes: APPBP1 Protein, CG7828 Protein, Dmel\\CG7828 Protein, anon-WO0140519.225 Protein, dAPP-BP1 Protein, dAPPBP1 Protein, A-116A10.1 Protein, ula-1 Protein, Appbp1 Protein, 59kDa Protein, appbp1 Protein, zgc:66148 Protein, beta-Amyloid precursor protein binding protein 1 Protein, NEDD8 activating enzyme E1 subunit 1 Protein, NEDD8 activating enzyme E1 subunit 1 S homeolog Protein, nedd8 activating enzyme E1 subunit 1 Protein, NEDD8-activating enzyme E1 regulatory subunit Protein, APP-BP1 Protein, NAE1 Protein, Nae1 Protein, nae1.S Protein, nae1 Protein, ula-1 Protein

Sujet: NAE1 (NEDD8-activating enzyme E1 regulatory subunit) belongs to the ubiquitin-activating E1 family. This protein binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. NAE1 participates in a novel ubiquitinylation-related pathway involving the ubiquitin-like molecule NEDD8. Also, this protein is required for cell cycle progression through the S/M checkpoint. Recombinant human NAE1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: NEDD8 activating enzyme E1 subunit 1, A-116A10.1, APPBP1, HPP1, ula-1. NCBI no.: NP_003896

Poids moléculaire: 62.7kDa (557aa)