IL12RB1 Protein (AA 24-540) (Fc Tag)
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- Antigène Voir toutes IL12RB1 Protéines
- IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 24-540
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette IL12RB1 protéine est marqué à la Fc Tag.
- Séquence
- AA 24-540
- Pureté
- >95 % as determined by reduced SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product IL12RB1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
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- Antigène
- IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
- Autre désignation
- IL-12 R beta 1 (IL12RB1 Produits)
- Synonymes
- Il12rb Protein, IL12RB1 Protein, IL-12R Protein, CD212 Protein, IL-12R-BETA1 Protein, IL12RB Protein, IL-12R[b] Protein, interleukin 12 receptor subunit beta 1 Protein, interleukin 12 receptor, beta 1 Protein, Il12rb1 Protein, IL12RB1 Protein
- Sujet
- The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
- Poids moléculaire
- 83.5 kDa
- NCBI Accession
- NP_005526
- Pathways
- Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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