Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) (AA 39-426) protein (His tag)

N° du produit ABIN6938865

Détail du produit

Antigène: Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)

Type de proteíne: Recombinant

Attributs du protein: AA 39-426

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: His tag

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 40 mM HEPES, 120 mM NaCl, pH 7.5

Stock: -20 °C

Détail du antigène

Antigène: Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB)

Autre désignation: CBLB (CBLB Produits)

Synonymes: rnf56 Protein, cblb Protein, AI429560 Protein, AI851073 Protein, Cbl-b Protein, Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog Protein, Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog Protein, Casitas B-lineage lymphoma b Protein, Cbl proto-oncogene B Protein, cblb.S Protein, cblb.L Protein, Cblb Protein, CBLB Protein

Sujet: Casitas B-lineage lymphoma proto-oncogene b (CBLB) is also known as RNF56. E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle.

Poids moléculaire: 47.0 kDa

NCBI Accession: NP_733762