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FOLR1 Protein (AA 25-233) (His tag)

FOLR1 Origine: Humain Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
N° du produit ABIN6952269
  • Antigène Voir toutes FOLR1 Protéines
    FOLR1 (Folate Receptor 1 (Adult) (FOLR1))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 25-233
    Origine
    • 17
    • 7
    • 4
    • 3
    • 3
    • 3
    Humain
    Source
    • 23
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette FOLR1 protéine est marqué à la His tag.
    Séquence
    AA 25-233
    Pureté
    >95 % as determined by SDS-PAGE.
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product FOLR1 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    50 mM Tris, 100 mM Glycine, pH 7.5
    Conseil sur la manipulation
    Please avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
  • Antigène
    FOLR1 (Folate Receptor 1 (Adult) (FOLR1))
    Autre désignation
    FOLR1 (FOLR1 Produits)
    Synonymes
    FBP Protein, FOLR Protein, fbp Protein, folr Protein, folr1 Protein, FBP1 Protein, Folbp-1 Protein, Folbp1 Protein, Fbp1 Protein, FOLR1 Protein, Folr1 Protein, folate receptor 1 Protein, folate receptor 1 (adult) Protein, folate receptor 1 (adult) L homeolog Protein, zgc:165502 Protein, Folate receptor alpha Protein, folate receptor alpha Protein, FOLR1 Protein, folr1 Protein, folr1.L Protein, zgc:165502 Protein, Folr1 Protein, LOC100066084 Protein, LOC100725439 Protein
    Sujet
    Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.
    Poids moléculaire
    26.5 kDa
    NCBI Accession
    NP_057937
    Pathways
    Dicarboxylic Acid Transport
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