FOLR1 Protein (AA 25-233) (His tag)

N° du produit ABIN7274662

Détail du produit

Antigène: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Type de proteíne: Recombinant

Attributs du protein: AA 25-233

Origine: Macaque rhésus, Cynomolgus

Source: HEK-293 Cells

Purification/Conjugué: Cette FOLR1 protéine est marqué à la His tag.

Fonction: Cynomolgus/Rhesus macaque FOLR1 Protein

Séquence: Arg25-Met233

Attributs du produit: Recombinant Cynomolgus/Rhesus macaque FOLR1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Arg25-Met233.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Cynomolgus/Rhesus macaque FOLR1, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-FOLR1 Antibody, hFc Tag with the EC50 of 12.6ng/ml determined by ELISA. See testing image for detail.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Autre désignation: FOLR1 (FOLR1 Produits)

Synonymes: FBP Protein, FOLR Protein, fbp Protein, folr Protein, folr1 Protein, FBP1 Protein, Folbp-1 Protein, Folbp1 Protein, Fbp1 Protein, FOLR1 Protein, Folr1 Protein, folate receptor 1 Protein, folate receptor 1 (adult) Protein, folate receptor 1 (adult) L homeolog Protein, zgc:165502 Protein, Folate receptor alpha Protein, folate receptor alpha Protein, FOLR1 Protein, folr1 Protein, folr1.L Protein, zgc:165502 Protein, Folr1 Protein, LOC100066084 Protein, LOC100725439 Protein

Sujet: Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH .

Poids moléculaire: 25.6 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Tris-Bis PAGE result.

NCBI Accession: NP_001181576

UniProt: A0A2K5U044

Pathways: Dicarboxylic Acid Transport