CCR3 Protein (Fc Tag)

N° du produit ABIN6964390

Détail du produit

Antigène: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CCR3 protéine est marqué à la Fc Tag.

Fonction: Recombinant human CCR3 protein with C-terminal human Fc tag

Specificité: CCR3 (Met1-Ala34) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Purification: affinity purification

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Agent conservateur: Without preservative

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Autre désignation: CCR3 (CCR3 Produits)

Synonymes: CC-CKR-3 Protein, CD193 Protein, CKR3 Protein, CMKBR3 Protein, CC-CKR3 Protein, Cmkbr1l2 Protein, Cmkbr3 Protein, C-C motif chemokine receptor 3 Protein, chemokine (C-C motif) receptor 3 Protein, CCR3 Protein, Ccr3 Protein

Sujet: Synonymes: CC-CKR-3, CD193, CKR3, CMKBR3
Description: The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

Poids moléculaire: predicted molecular mass of 29.9 kDa after removal of the signal peptide. The apparent molecular mass of CCR3-hFc is 35-55 kDa due to glycosylation.

UniProt: P51677