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IL13RA2 Protein (AA 27-343) (Fc Tag)

IL13RA2 Origine: Humain Hôte: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
N° du produit ABIN6973106
  • Antigène Voir toutes IL13RA2 Protéines
    IL13RA2 (Interleukin 13 Receptor, alpha 2 (IL13RA2))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 27-343
    Origine
    • 14
    • 7
    • 4
    • 2
    • 1
    Humain
    Source
    • 14
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette IL13RA2 protéine est marqué à la Fc Tag.
    Attributs du produit
    Human IL-13 R alpha 2 Protein, Fc Tag (MALS verified)
    Pureté
    >90 % as determined by SDS-PAGE.
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product IL13RA2 Protéine
  • Indications d'application
    MALS verified
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Stock
    -20 °C
  • Antigène
    IL13RA2 (Interleukin 13 Receptor, alpha 2 (IL13RA2))
    Autre désignation
    IL-13 R alpha 2 (IL13RA2 Produits)
    Synonymes
    il-13ra2 Protein, sb:cb602 Protein, si:dkeyp-110c7.6 Protein, CD213A2 Protein, CT19 Protein, IL-13R Protein, IL13BP Protein, CD213a2 Protein, IL-13R-alpha-2 Protein, IL13RA2 Protein, interleukin 13 receptor, alpha 2 Protein, interleukin 13 receptor subunit alpha 2 Protein, interleukin 13 receptor subunit alpha 2 S homeolog Protein, il13ra2 Protein, IL13RA2 Protein, il13ra2.S Protein, Il13ra2 Protein
    Sujet
    Interleukin-13 receptor subunit alpha-2 is also known as IL13Rα2, IL13Ra2 cluster of differentiation 213A2, CD213A2, CT19, IL-13R, IL13BP, and is a membrane bound protein that in humans is encoded by the IL13RA2 gene. IL13Rα2 is closely related to IL13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL13 and IL4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13. IL13Rα2 is a component of the cell surface receptors, however, the majority exists in intracellular pools and in soluble form, and thus plays an opposite role as a potent IL13 antagonist compared with IL13Rα1. It also functions as an inhibitor of IL4-dependent pathway probably through the physical interaction between the short intracellular domain of and cytoplasmic domain of IL13Rα2 and the IL4Rα chain. In spite of the failed STAT signaling function, IL13Rα2 dose induce TGF-beta production and fibrosis. Additionally, IL13Rα2has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme.
    Poids moléculaire
    63.5 kDa
    NCBI Accession
    NP_000631
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