LOXL2 Protein (AA 26-774) (His tag)
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- Antigène Voir toutes LOXL2 Protéines
- LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 26-774
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette LOXL2 protéine est marqué à la His tag.
- Fonction
- Human LOXL2 Protein, His Tag (active enzyme)
- Pureté
- >95 % as determined by reduced SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product LOXL2 Protéine
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 20 mM MES, 50 mM NaCl, pH 6.5
- Stock
- -80 °C
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- Antigène
- LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))
- Autre désignation
- LOXL2 (LOXL2 Produits)
- Synonymes
- LOR2 Protein, WS9-14 Protein, CG4402 Protein, Dmel\\CG4402 Protein, Dmloxl-2 Protein, dmlox-2 Protein, 1110004B06Rik Protein, 4930526G11Rik Protein, 9430067E15Rik Protein, GB13360 Protein, lox2-like Protein, LOXL2 Protein, lor2 Protein, loxl-2 Protein, ws9-14 Protein, im:7136137 Protein, si:dkeyp-32b1.1 Protein, wu:fk12g04 Protein, zgc:158414 Protein, lysyl oxidase like 2 Protein, lysyl oxidase-like 2 Protein, lysyl oxidase homolog 4 Protein, lysyl oxidase like 2 L homeolog Protein, lysyl oxidase-like 2b Protein, LOXL2 Protein, lox2 Protein, Loxl2 Protein, LOC408544 Protein, loxl2.L Protein, loxl2 Protein, loxl2b Protein
- Sujet
- Lysyl oxidase homolog 2 is also known as LOXL2, Lysyl oxidase-like protein 2, which is expressed in many tissues, highest expression in reproductive tissues, placenta, uterus and prostate, Up-regulated in a number of cancers cells and tissues. LOXL2 mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOXL2 acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. LOXL2 acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
- Poids moléculaire
- 86.0 kDa
- NCBI Accession
- NP_002309
- Pathways
- Chromatin Binding
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