NRG1-beta 1 Protein (AA 2-246) (Fc Tag)

N° du produit ABIN7013440

Détail du produit

Antigène: NRG1-beta 1 (Neuregulin-1 beta 1 (NRG1-beta 1))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 2-246

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette NRG1-beta 1 protéine est marqué à la Fc Tag.

Attributs du produit: Human NRG1 Beta 1 Protein, Fc Tag

Pureté: >90 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Détail du antigène

Antigène: NRG1-beta 1 (Neuregulin-1 beta 1 (NRG1-beta 1))

Autre désignation: NRG1 Beta 1 (NRG1-beta 1 Produits)

Sujet: NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specific and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains, and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through their displayed interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.

Poids moléculaire: 53.2 kDa

NCBI Accession: NP_039250