APP Protein (His tag)
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- Antigène Voir toutes APP Protéines
- APP (Amyloid beta (A4) Precursor Protein (APP))
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette APP protéine est marqué à la His tag.
- Fonction
- Recombinant Human APP Protein with C-terminal 6xHis tag
- Specificité
- APP (Leu18-Val669) 6xHis Tag
- Attributs du produit
- Extracellular Domain Protein
- Purification
- affinity purification
- Pureté
- The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
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- Discover our top product APP Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with deionized water
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Date de péremption
- 12 months
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- Antigène
- APP (Amyloid beta (A4) Precursor Protein (APP))
- Autre désignation
- APP (APP Produits)
- Synonymes
- AAA Protein, ABETA Protein, ABPP Protein, AD1 Protein, APPI Protein, CTFgamma Protein, CVAP Protein, PN-II Protein, PN2 Protein, aaa Protein, abeta Protein, abpp Protein, ad1 Protein, appi Protein, ctfgamma Protein, cvap Protein, pn2 Protein, APP Protein, APP-like Protein, APPL Protein, Abeta Protein, BcDNA:GH04413 Protein, CG7727 Protein, Dmel\\CG7727 Protein, EG:65F1.5 Protein, appl Protein, Abpp Protein, Adap Protein, Ag Protein, Cvap Protein, E030013M08Rik Protein, betaApp Protein, app Protein, wu:fj34d10 Protein, wu:fk65e12 Protein, zgc:85740 Protein, amyloid beta precursor protein Protein, amyloid beta (A4) precursor protein Protein, beta amyloid protein precursor-like Protein, amyloid beta (A4) precursor protein a Protein, amyloid beta precursor protein L homeolog Protein, APP Protein, app Protein, Appl Protein, App Protein, appa Protein, app.L Protein
- Sujet
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Synonymes: AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, preA4
Description: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014] - Poids moléculaire
- predicted molecular mass of 74.6 kDa after removal of the signal peptide.The apparent molecular mass of APP-His is 100-130 kDa due to glycosylation.
- UniProt
- P05067
- Pathways
- Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
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