C-Type Lectin Domain Family 1, Member B (CLEC1B) (Active) protein (His tag)

N° du produit ABIN7194470

Détail du produit

Antigène: C-Type Lectin Domain Family 1, Member B (CLEC1B)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: His tag

Fonction: Recombinant Human CLEC1B/CLEC2 Protein (His Tag)(Active)

Séquence: Gln 58-Pro 229

Attributs du produit: A DNA sequence encoding the human CLEC1B (NP_057593.3) extracellular domain (Gln 58-Pro 229) with a N-terminal polyhistidine tag was expressed.

Pureté: > 76 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized human Podoplanin at 10 μg/mL (100 μl/well) can bind  biotinylated human CLEC1B-His, The EC50 of biotinylated human CLEC1B-His is 0.71 μg/mL.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: C-Type Lectin Domain Family 1, Member B (CLEC1B)

Autre désignation: CLEC1B/CLEC2 (CLEC1B Produits)

Synonymes: 1810061I13Rik Protein, CLEC2 Protein, CLEC2B Protein, PRO1384 Protein, QDED721 Protein, Clec-2 Protein, Clec2 Protein, CLEC1B Protein, RGD1563517 Protein, CLEC9A Protein, C-type lectin domain family 1 member B Protein, C-type lectin domain family 1, member b Protein, C-type lectin domain family 1, member B Protein, CLEC1B Protein, Clec1b Protein

Classe de substances: Viral Protein

Sujet:

Background: CLEC1B, also known as CLEC2, is a C-type lectin-like receptor expressed in myeloid cells and NK cells. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 and NKG2D, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. CLEC2 contains 1 C-type lectin domain and is expressed preferentially in the liver. It acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.

Synonym: 1810061I13Rik,CLEC2,CLEC2B,PRO1384,QDED721

Poids moléculaire: 22.7 kDa

NCBI Accession: NP_057593