C-Type Lectin Domain Family 4, Member M (CLEC4M) protein (Fc Tag)

N° du produit ABIN7194490

Détail du produit

Antigène: C-Type Lectin Domain Family 4, Member M (CLEC4M)

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Fc Tag

Fonction: Recombinant Human DC-SIGNR/CD299/CLEC4M Protein (Fc Tag)

Séquence: Ser 78-Glu 399

Attributs du produit: A DNA sequence encoding the extracellular domain (Ser 78-Glu 399) of human DC-SIGNR (NP_055072.3) was fused with the Fc region of human IgG1 at the N-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: C-Type Lectin Domain Family 4, Member M (CLEC4M)

Autre désignation: DC-SIGNR/CD299/CLEC4M (CLEC4M Produits)

Synonymes: CD209L Protein, CD299 Protein, DC-SIGN2 Protein, DC-SIGNR Protein, DCSIGNR Protein, HP10347 Protein, L-SIGN Protein, LSIGN Protein, CD209B Protein, C-type lectin domain family 4 member M Protein, CLEC4M Protein

Sujet:

Background: C-type lectin domain family 4, member M, also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein that is 77 % amino acid identical to DC-SIGN, an HIV gp120-binding protein. Though the encoded gene located in the same chromosome, DC-SIGN is expressed solely on dendritic cells, while DC-SIGNR is predominantly found in liver sinusoidal endothelial cells and lymph node, as well as placental endothelium. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. DC-SIGNR appears to selectively recognize and bind many viral surface glycoproteins containing high mannose N-linked oligosaccharides in a calcium-dependent manner, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S, as well as the cellular adhesion protein ICAM3. DC-SIGNR have been thought to play an important role in establishing HIV infection by enhancing trans-infection of CD4(+)T cells in the regional lymph nodes. It may affect susceptibility to HIV infection by a mechanism that is different in females and males. DC-SIGNR can bind to hepatitis C virus (HCV), and its polymorphism might affect HCV loads supporting the concept that DC-SIGNR contributes to HCV replication efficacy.

Synonym: CD209L,CD299,CLEC4M,DC-SIGN2,DC-SIGNR,DCSIGNR,HP10347,L-SIGN,LSIGN,MGC129964,MGC47866

Poids moléculaire: 65 kDa

NCBI Accession: NP_055072