CAMK2A Protein (GST tag)

N° du produit ABIN7317100

Détail du produit

Antigène: CAMK2A (Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette CAMK2A protéine est marqué à la GST tag.

Fonction: Recombinant Human CAMK2A/CAMKA Protein (GST Tag)(Active)

Séquence: Met 1-His 478

Attributs du produit: A DNA sequence encoding the human CAMK2A isoform 2 (NP_741960.1) (Met 1-His 478) was fused with the GST tag at the N-terminus.

Pureté: > 85 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 160 nmol/min/mg using Autocamtide-2 synthetic peptide (KKALRRQETVDAL-amide) as substrate.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, 0.5 mM Reduced Glutathione, pH 8.0

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: CAMK2A (Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A))

Autre désignation: CAMK2A/CAMKA (CAMK2A Produits)

Synonymes: camk2 Protein, camk2b Protein, zgc:112538 Protein, zgc:123320 Protein, CAMKA Protein, CaMKII Protein, R74975 Protein, mKIAA0968 Protein, PK2CDD Protein, PKCCD Protein, calcium/calmodulin dependent protein kinase II alpha Protein, calcium/calmodulin dependent protein kinase (CaM kinase) II alpha S homeolog Protein, calcium/calmodulin-dependent protein kinase II alpha Protein, CAMK2A Protein, camk2a.S Protein, camk2a Protein, Camk2a Protein

Sujet:

Background: Ca2+/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+/ calmodulin-dependent protein kinase subfamily. CaM kinase II is thought to be an important mediator of learning and memory and is also necessary for Ca2+ homeostasis and reuptake in cardiomyocytes chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CAMKIIA is one of the major forms of CAMKII. It has been found to play a critical role in sustaining activation of CAMKII at the postsynaptic density. Studies have found that knockout mice without CAMKIIA demonstrate a low frequency of LTP. Additionally, these mice do not form persistent, stable place cells in the hippocampus.

Synonym: CAMKA

Poids moléculaire: 80.3 kDa

NCBI Accession: NP_741960

Pathways: Signalisation WNT, Interferon-gamma Pathway, Myometrial Relaxation and Contraction