Calnexin Protein (CANX) (His tag)

N° du produit ABIN7318226

Détail du produit

Antigène: Calnexin (CANX)

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette Calnexin protéine est marqué à la His tag.

Fonction: Recombinant Human Calnexin/CANX Protein (His Tag)

Séquence: His21-Pro481

Attributs du produit: Recombinant Human Calnexin is produced by our Mammalian expression system and the target gene encoding His21-Pro481 is expressed with a 6His tag at the C-terminus.

Pureté: > 85 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, 2 mM CaCl, 10 % Glycerol, pH 7.5.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: Calnexin (CANX)

Autre désignation: Calnexin/CANX (CANX Produits)

Synonymes: CNX Protein, IP90 Protein, P90 Protein, 1110069N15Rik Protein, AI988026 Protein, Cnx Protein, D11Ertd153e Protein, canx Protein, clgn Protein, clnx Protein, cnx Protein, PP90 Protein, zgc:63524 Protein, wu:fe06b12 Protein, CANX Protein, calnexin Protein, CalNeXin Protein, calnexin L homeolog Protein, CANX Protein, Canx Protein, cnx-1 Protein, canx.L Protein, canx Protein, LOC100283947 Protein

Sujet:

Background: Calnexin/CANX is a single-pass type I membrane protein which belongs to the calreticulin family. It consists of a large N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail. The function of calnexin is to retain unfolded or unassembled N-linked glycoproteins in the endoplasmic reticulum. Calnexin is a calcium-binding protein that interacts briefly with newly synthesized glycoproteins in the endoplasmic reticulum. Calnexin may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. Calnexin seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Calnexin dwindles with aging and might contribute to a cytoprotection in an array of human age-related diseases.

Synonym: Calnexin, IP90, Major Histocompatibility Complex Class I Antigen-Binding Protein p88, p90, CANX

Poids moléculaire: 53.5 kDa

UniProt: P27824

Pathways: Signalisation MAPK, Thyroid Hormone Synthesis