cGMP-Dependent 3',5'-Cyclic Phosphodiesterase (PDE2A) (AA 215-900) protein (His tag)

N° du produit ABIN7317321

Détail du produit

Antigène: cGMP-Dependent 3',5'-Cyclic Phosphodiesterase (PDE2A)

Type de proteíne: Recombinant

Attributs du protein: AA 215-900

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: His tag

Fonction: Recombinant Human PDE2A/CGS-PDE Protein (aa 215-900, His Tag)

Séquence: Glu 215-His 900

Attributs du produit: A DNA sequence encoding the amino acids (Glu 215-His 900) of human PDE2A (O00408-1) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: cGMP-Dependent 3',5'-Cyclic Phosphodiesterase (PDE2A)

Autre désignation: PDE2A/CGS-PDE

Sujet:

Background: cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein which belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac contractility, platelet aggregation, lipolysis, glycogenolysis, and smooth muscle contraction. PDE2A is an evolutionarily conserved cGMP-stimulated cAMP and cGMP PDE. PDE2A contains two GAF domains. PDE2A is expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas. PDE2A is a cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. PDE2A is involved in the regulation of blood pressure and fluid homeostasis by the atrial natriuretic peptide (ANP), making PDE2-type enzymes important targets for drug discovery.

Synonym: CGS-PDE;cGSPDE;PDE2A1;PED2A4

Poids moléculaire: 80.0 kDa